Vijg argues that findings in model organisms aren’t necessarily applicable to humans because these animals are bred to have certain traits. And at least one lifespan-extending strategy, caloric restriction, is much  less effective when used in wild mice or monkeys, he says. “I’m not saying drugs or tissue engineering couldn’t be very beneficial to increase our average lifespan, but will they really enable us to break through this ceiling of 115? I find that highly unlikely,” Vijg says.  “Lifespan is controlled by too many genes. You could maybe plug one of those holes, but there are still another 10,000 other holes springing up.”
Biomedical gerontologist Aubrey de Grey, chief
 science officer of the SENS Research Foundation Mountain View, California, which develops and promotes rejeuvenation biotechnologies, is more hopeful. “Unlike a dam, the pressure on the so-far-unplugged leaks actually diminishes as one plugs more and more of them,” he says. “The result in this paper is absolutely correct, but it says nothing about the potential of future medicine, only the performance of today’s and yesterday’s medicine.”